High dose of bolus iron vs. low dose of weekly infusion: bolusing high dose, a recipe for iron toxicity?
نویسنده
چکیده
Sir, We read with interest the article by Kosch et al. w1x comparing the i.v. infusion of iron sucrose with iron gluconate in patients on haemodialysis. Although this study provides some direct comparative analysis between two forms of parenteral iron compounds, the implication that iron sucrose being a monthly bolus dose might be better than the more frequently, Nephrol Dial Transplant (2002) 17: 939–946
منابع مشابه
Acute toxicity investigation regarding clinical and pathological aspects following repeated oral administration of iron oxide nanoparticles in rats
Iron oxide nanoparticles (IONPS) have potential different applications in nanomedicine. These new applications of IONPS have raised exposure risk of this nanomaterials to humans. Up to now, all aspects of IONPS toxicity are not fully clear following animal’s exposure with these novel compounds. This study aimed to investigate the acute toxicity effects of IONPS in laboratory animals regarding p...
متن کاملIntravenous Iron Supplementation Practices and Short-Term Risk of Cardiovascular Events in Hemodialysis Patients
BACKGROUND & OBJECTIVES Intravenous iron supplementation is widespread in the hemodialysis population, but there is uncertainty about the safest dosing strategy. We compared the safety of different intravenous iron dosing practices on the risk of adverse cardiovascular outcomes in a large population of hemodialysis patients. DESIGN SETTINGS PARTICIPANTS & MEASUREMENTS A retrospective cohort w...
متن کاملThe Evaluation of Deferasirox on Hematological Parameters after Lead Administration
Background: Metals such as iron, zinc, and copper are critical and necessary for the survival of all living organisms, whereas xenobiotic metals such as lead, cadmium, mercury, and arsenic have no known biologic role. Any metals in high doses can have toxic effects. The aim of this work was to evaluate the hematological changes induced by lead as a toxic metal and characterize the potential eff...
متن کاملEfficacy of different doses of ketamine as a bolus in major depressive disorder
Background: Major depressive disorder is a severe, heterogeneous, common medical illness and a leading cause of disability throughout the world that poses a significant public health issue. Previous studies have shown rapid antidepressant effects following a single administration of ketamine. This study aimed to assess the impact of route of administration and dose of ketamine for the reduction...
متن کاملINTESTINAL ZINC ABSORPTION IN DESFERROXAMINE-TREATED RATS
Desferroxamine (Desferal) is used tochelate iron in thalassemia, a disease of very high prevalence in various parts of lran. We have investigated intestinal zinc absorption in Desferal-treated rats which, in pilot experiments, showed low serum levels of both iron and zinc. Intraperitoneal administration of ten 0.5 g doses of Desferal (one injection every other day) to male rats produced sev...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
دوره 17 5 شماره
صفحات -
تاریخ انتشار 2002